SSMD Threshold
|
Number of replicated hits
|
Number screened
|
Percentage hits
|
---|
Below -0.5
|
38
|
2000
|
1.9 %
|
Below -1.0
|
7
|
2000
|
0.35 %
|
Above 1.0
|
20
|
2000
|
1 %
|
Caused Death
|
142
|
2000
|
7.1 %
|
- Compounds that showed similar activity in both trials were identified as hits using the SSMD* threshold criteria as above. SSMD* below -0.5 are inhibitors of neuronal stress and those above 1.0 are activators of the neuronal heat-shock stress response