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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

Fig. 1

Quantification of BIN1 transcript levels in brains with and without AD. a Scatter plot of the normalized levels of BIN1 isoforms generated by alternative splicing of exon 7 in each sample (quantified by qPCR analysis) reveals a lack of correlation between D7 + Ex7 and D7-BIN1 expression. b qPCR analysis of BIN1 exon 7 alternative splicing in the human brain shows a significantly higher proportion of BIN1 transcripts lacking exon 7 in white matter (WM) as compared with gray matter (GM). cf Scatter plots of BIN1 + Ex7 and D7-BIN1 expression compared to SYP (synaptophysin) and MBP expression. AD = AD; Norm = normalized expression. The indicated R2 values (A, C-F) are adjusted R2 values, reflecting the presence of two independent variables in the analysis, i.e., AD status and BIN1, SYP or MBP expression

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