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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy

Fig. 1

Acute 4E6- but not 6B2 therapy improved spatial learning and memory in htau mice. a 4E6 immunized mice showed significant improvements in Closed Field Symmetrical (CFS) Maze (48 % fewer errors, p < 0.01), compared to their pre-immunization performance, whereas control IgG treated mice did not improve. When divided by gender, both males and females treated with 4E6 showed significant improvement over their pre-treatment performance (52 and 44 % fewer errors, p < 0.01 and p < 0.05, respectively, see text for average and SEM) Repeated measures, two-way ANOVA revealed a significant effect of treatment (p = 0.0018) but not of gender (p = 0.5145), indicating that the results seen are not attributable to gender differences. In contrast, animals treated with IgG did not show improvement when all animals were considered together, or when divided by gender. b 6B2 treated mice also did not improve in the same test. **: p < 0.01

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