Fig. 4

LTP in Atm−/− animals can be improved by dietary supplementation with glutamine. a. Plots of fEPSP slope, normalized to baseline, showing the responses of Atm−/− animals to the 6xTBS induction protocol. After 10 min of baseline recording, the TBS train was delivered at time = 0. Filled symbols show the average response of animals that received glutamine. Dotted line shows the average response of untreated Atm−/− animals from a separate parallel study [23]. b. Input–output plot of fEPSP slope in response to single pulses of increasing amplitude. Stimulus intensities of 10, 20, 40, 60, 80, 100, and 120 μA were tested. There was not a significant difference between Atm−/− animals with and without glutamine (p > 0.3, t-test, two-sided). Error bars = standard deviations