Fig. 5

Glutamine supplementation significantly increases the life span of Atm ^−/− mice. a Kaplan-Meyer curves of the mice. Atm ^−/− mice on normal diet (control, squares) had a mean lifespan of 85 days (16 females and 7 males); Atm ^−/− mice with glutamine supplementation (circles) had a mean lifespan of 120 days (13 females and 6 males). The significance of the difference between the glutamine and control curves was determined by the Mantel-Cox log-rank test. b Glutamine significantly extends life span of both male and female Atm ^−/− mice. The mean age at death is plotted separately for male (M) and female (F) Atm ^−/− mice either with (Gln) or without (Cont) dietary glutamine supplementation. Statistically different by two-tailed t-test: ***, p < 0.001; **, p < 0.01. Values represent means and standard errors