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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment

Fig. 8

Glutamine deprivation leads to significant reduction in ATM and mTOR concentrations in neurons. a Both endogenous and exogenous glutamine are required for stable concentrations of ATM and 53BP1 in neurons. b Glutamine and ATM interact to modulate mTOR concentration and mTOR activity. The symbols above the lanes indicate the presence (+) or absence (−) of 2 mM Glutamax (gln), 5 mM methionine sulfoximine (mso), a glutamine synthase inhibitor or 10 μM KU55993 (Ku), an ATM inhibitor

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