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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice

Fig. 2

Relative O.D. values of the striatal samples immunostained for glial markers. Relative O.D values, representing inflammatory responses to various treatments, were calculated for the microglial marker IBA1 (a) and the reactive astroglial marker GFAP (b), at 4 and 6 weeks after injection. Unoptimized ZF-KOX1 treatment was compared to expression of a host optimized mZF-KRAB, GFP or a control PBS injection. Relative O.D. is calculated as the mean O.D. of four coronal slices, separated by 240 μm in the injected hemisphere, minus the average O.D. in the contralateral control hemisphere. Data are displayed as Relative O.D. ± S.E.M, *** P < 0.001, **P < 0.01, *P < 0.05

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