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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice

Fig. 4

Astroglial activation in the striatum and cortex after various treatments. Representative micrographs of GFAP immunostained striatal coronal slices for the control and injected hemispheres, for each treatment at each time point. ZF-KOX1 samples displayed a strong and sustained increase in GFAP immunoreactivity in the injected hemispheres, 4 and 6 weeks after treatment (a, b). In contrast, mZF-KRAB treatment provoked a transient upregulation of GFAP immunoreactivity, which started to decline at 6 weeks post-injection (c, d). GFAP immunoreactivity after GFP injections followed the pattern of Iba1 staining, with a slight increase 4 weeks post-treatment and significant signal increase at 6 weeks post-treatment (e, f). Isolated, non-reactive astrocytes can be observed at PBS-injected samples and their contralateral hemispheres (a’, b’, c’, d’, e’, d’, g, g’, h, h’). Scale bar: 100 μm

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