TY - JOUR AU - Sogorb-Esteve, Aitana AU - García-Ayllón, María-Salud AU - Fortea, Juan AU - Sánchez-Valle, Raquel AU - Lleó, Alberto AU - Molinuevo, José-Luis AU - Sáez-Valero, Javier PY - 2016 DA - 2016/09/29 TI - Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease JO - Molecular Neurodegeneration SP - 66 VL - 11 IS - 1 AB - Presenilin-1 (PS1), the active component of the intramembrane γ-secretase complex, can be detected as soluble heteromeric aggregates in cerebrospinal fluid (CSF). The aim of this study was to examine the different soluble PS1 complexes in the lumbar CSF (CSF-PS1) of individuals with Alzheimer’s disease (AD), particularly in both symptomatic and asymptomatic genetically determined AD, in order to evaluate their potential as early biomarkers. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-016-0131-2 DO - 10.1186/s13024-016-0131-2 ID - Sogorb-Esteve2016 ER -