Fig. 1

Characterization of the CSF-PS1 complexes in younger and elderly NC subjects, and their correlation with age. a Representative Western blots of human CSF samples from non-demented control (NC) subjects arbitrarily categorized as young (yNC; ≤60 years; n = 23) and elderly (eNC; >60 years; n = 17), and probed with an anti-NTF-PS1 antibody. b Densitometric quantification of the major 100 and 150 kDa CSF-PS1 complexes (the sum of the 100 + 150 kDa CSF-PS1 bands) and the quotient derived from the immunoreactivity for the 100 and 150 kDa bands relative to that for the minor 50 kDa band in each sample [(100 + 150 kDa)/50 kDa]. The data represent the means ± SEM and they were compared using a paired Students t test: *p <0.001. c Correlation between the levels of the 100 + 150 kDa CSF-PS1 complexes with age