Fig. 4

An increase in PS1 stable complexes in DS CSF. a Representative blot of PS1 complexes in CSF from 10 DS subjects with dementia of the Alzheimer’s type (dDS), 10 DS without any sign of memory decline (ndDS) and 23 yNC. b Densitometric quantification of the accumulated immunoreactivity from the sum of the higher molecular mass PS1 complex (100 + 150 kDa), and the quotient of the (100 + 150 kDa) immunoreactivity relative to the 50 kDa immunoreactivity (100 + 150 kDa/50 kDa). The means ± SEM are shown: *p <0.005, **p <0.005, Student t test