Fig. 3
From: Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling
Immunofluorescent analysis of glia activation in the spinal cord after crush injury of the sciatic nerve. a CD11b (microglia) and GFAP (astrocytes) in SLICK-Grn mice (without tamoxifen), SLICK-Grn-OE mice (with tamoxifen) and Grn−/− mice. The circled area in the upper panel showing the glia activation around the injured motor neurons was used for magnification. Scale bars 200 μm. b 2D intensity profile plots of the rectangles shown in the middle and bottom panels in a. The AUCs of the profile plots differed significantly between groups c AUCs of the intensity profile plots (*one-way ANOVA, P < 0.05, posthoc Dunnett versus SLICK-Grn (without tamoxifen) control mice, n = 3)