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Fig. 9 | Molecular Neurodegeneration

Fig. 9

From: Spinal cord injury induces astroglial conversion towards neuronal lineage

Fig. 9

Schematic cartoon illustrating the overall astrocytic response after SCI. Astrogliosis after SCI depends on both time post-injury and lesion severity. At 1 week after HS astrocytes undergo moderate activation and do not promote an immune response by 2 weeks after HS SCI. On the other hand, at 1 week following FT astrocytes undergo marked activation and actively promote immune response/inflammation followed by reduced extracellular membrane breakdown at 2 weeks after FT. Concurrently, a sub-population of local astrocytes transdifferentiates into neuronal progenitor and subsequently GABAergic interneurons via fgfr4 over-expression

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