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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

Fig. 2

Increase of Aβ production and Tau phosphorylation in aged APN-KO mice. a Immunohistochemistry analysis of anti-Aβ (4G8) showed accumulation of Aβ (Brown) in the cortex of 18-month APN-KO mice. b ELISA analysis of soluble Aβ1–42 in the hippocampal and frontal cortical lysate of 9-month and 18-month old mice. c Immunoblotting of mouse Aβ by antibody 4G8 showing the presence of Aβ*56 in the hippocampus and frontal cortex of 18-mth old APN-KO mice. d Immunoblotting of pTau serine199 & 202, pTau serine396 and Tau5 (total tau) in the hippocampus and frontal cortex of 18-mth old mice. Mean ± S.E.M.; *p < 0.05, **p < 0.01, n.s. statistically not significant; WT (n = 4) vs APN-KO (n = 6). Scale bar: 50 μm

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Molecular Neurodegeneration

ISSN: 1750-1326