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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

Fig. 2

Expression of total and alternative spliced TREM2 mRNA in AD and p.R47H carriers. Relative quantitation was performed using 2-ΔΔCt (fold change) method. For each sample in the AD or p.R47H group the fold change (FC) value is expressed relative to the median value of TREM2 in control (a) or WT group (b) that was set at 1. The median FC value in AD samples is 3.19 for TREM2 and 2.62 for TREM2alt; and in p.47H carriers is for TREM2 1.20 and 0.97 for TREM2alt. ***p < 0.0001. ns: not significant. c. Assessment of relative expression levels (2-ΔΔCt) for TREM2 or TREM2alt indicates a positive association in all the samples (controls and ADs) for both TREM2 transcripts with the microglial marker AIF1 (IBA1) (R square values of 0.32 and 0.25 for TREM2 and TREM2alt, respectively; and p < 0.0001 for both transcripts)

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