Skip to main content
Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

Fig. 10

Schematic diagram of our working model for apoE delivery and distribution by the glymphatic system. This schematic diagram shows the parenchymal distribution of CSF-derived apoE isoform-specific convective flow/bulk flow pattern (apoE2 > apoE3 > apoE4) around an artery. CSF-derived apoE is present on the vessel wall and around the artery. The apoE distribution is shown as a circle around the artery for simplicity but its bulk flow (unequal distribution around the artery). Within the brain there are many cells, such as neurons, astrocytes that express many membrane bound receptors that avidly binds apoE. Symbols: A - penetrating arteriole; V - vein; - apoE; - AQP4; There are many different types of apoE receptors, such as - apoE receptor mainly on astrocyte and - apoE receptor mainly on neuron

Back to article page