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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

Fig. 5

ApoE-isoform specific distribution around arteries. a-c Representative images of apoE2, apoE3 and apoE4 (colored red) radial distribution 15 min following their intracisternal injections. Scale bar 100 μm for the left panels and 50 μm for the middle/right panels. d Quantification of the distribution distance from the arteries. Values are mean ± SEM. N = 5–9. e FITC-apoE3 in the CSF binding to NeuN- positive neurons (red) in the vicinity of arteries. White arrows point to apoE3/NeuN- double positive cells (the image is 100 μm wide). The vasculature was outlined by intravascular labeling with lectin (blue)

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