Fig. 2
From: 3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”
Platform for AD drug screening in a 3D human neural cell culture model of AD. Typically, discovery of new AD drugs goes through three steps: Development and screening drugs in conventional 2D cell culture models of AD (Drug Discovery/Screening); followed by confirming the effects of drugs in AD transgenic mouse models (Preclinical Tests); and after their effects were confirmed both in cell culture and mouse models, drugs are further tested in humans (Clinical Trials). As compared to the conventional 2D cell cultures and animal models, 3D human cell culture models of AD can be more cost-effective and less time-consuming in developing novel AD drugs