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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord

Fig. 1

Gde2 mRNA and protein are expressed in the postnatal spinal cord. a Paneled epifluorescent image of fluorescent in-situ hybridization (FISH) using a Gde2 antisense probe showing broad expression in all spinal laminae (labeled I to X), as well as the corticospinal tract (CST), dorsal columns (DC), lateral funiculus (lf), and ventral funiculus (vf). Scale bar = 100 μm. bd Magnified regions indicated in panel A showing Gde2 expression in large diameter motor neurons (B), small diameter neurons (C), and glia (D). Arrows mark examples. Scale bar = 35 μm. e Gde2 sense probe shows no signal in the lumbar spinal cord. Dashed yellow lines = boundary between grey and white matter. Scale bar = 150 μm. f Western blot visualizing GDE2 protein (80kD band) in WT and not Gde2 KOs. n = 3

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