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Table 3 Drug-based and genetic methods used to induce a PD-like phenotype in SH-SY5Y cells

From: The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

PD-mimic

 

Single

Multiple

Total

MPP+

169

63

232

Manipulation of expression of familial genes

180

53

233

6-OHDA

141

47

188

Rotenone

69

56

125

Dopamine

33

26

59

H2O2

12

34

46

NM (R) Sal/Salsolinol

21

6

27

Paraquat

13

12

25

Lactacystin

8

11

19

Other treatments

  

112

  1. Listed are the most commonly used treatments to mimic PD in the SH-SY5Y cell line as well as the number of articles that use one (single) or, to validate the results, more than one (multiple) treatment. Other treatments include conditioned media from glial cells, MG132, SIN-1, staurosporine, thapsigargin, carbonyl cyanide m-chlorophenyl hydrazine (CCCP), tunicamycin, epoxomicin, bafilomycin, neuromelanin, miRNAs, A-β1, BmK1, L-buthionine-(S, R)-sulfoximine (BSO), Conduritol B epoxide (CBE), Ciplastin and PSI. MPP+: 1-methyl-4-phenylpyridinium; 6-OHDA: 6-hydroxydopamine; H2O2: hydrogen peroxide
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Molecular Neurodegeneration

ISSN: 1750-1326