Table 1 Tissue and cellular distribution of NOX isoforms

NOX1

NOXO1

NOXA1

Rac1

PKA

PKC

MAPK

Hsp90

Superoxide

Colon [35, 39, 42]

Blood vessels [70, 359, 360]

Heart [361]

Bone marrow [362]

Cochlea [103]

Cerebral cortex [53, 139]

Hippocampus [50, 202]

Cerebellum [363]

Substantia nigra [364]

Striatum [61]

Hypothalamus [361]

Cerebral vessels [359, 365]

NOX2

P67phox

P47phox

P40phox

Rac

Hsp90

Superoxide

Vasculature [365, 366]

Phagocytes [319, 367]

Heart [361, 368, 369]

Kidney [370]

Gastrointestinal tract [371]

Liver [372]

Pancreas [373]

Cochlea [103]

Cerebral cortex [71, 374, 375]

Hippocampus [132, 374, 376]

Cerebellum [363]

Striatum [377, 378]

Substantia nigra [379, 380]

Hypothalamus [361, 381]

Subfornical organ [382]

Lateral ventricle [383]

Subventricular zone [383]

Midbrain [380]

Nucleus tractus solitarius [384]

NOX3

NOXA1

NOXO1

Rac

p67phox

Superoxide

Inner ear/Cochlea [100, 102, 103, 385]

Lungs [386, 387]

Cerebral cortex [71]

NOX4

p22^phox

PolDip2

PDI

Hypoxia

mGlu3

PI3K

TLR4

Hydrogen peroxide

Ubiquitous, including:

Kidney [35, 39, 388]

Vessels [389, 390]

Lung [391–394]

Bone [39, 362, 395]

Placenta [35, 39, 396]

Cochlea [103]

Cerebral cortex [71, 377, 397]

Hippocampus [376]

Cerebellum [363]

Hypothalamus [361, 381, 398]

Subfornical organ [382]

Glioblastoma [35]

NOX5

Ca⁺²

Hsp90

Superoxide

Testis [35]

Ovary [35]

Spleen [35]

Kidney [399]

Vasculature [400, 401]

Uterus [402]

Cochlea [103]

Tumors [35, 115]

Glioblastoma [35, 116]

DUOX1

Ca²⁺

Duoxa1

Duoxa2

Hydrogen peroxide

Thyroid [34, 37]

Lung [354, 403, 404]

Skin [154, 156, 405]

Cochlea [103]

None reported

DUOX2

Ca²⁺

TRIF/NFkB

MyD88/p38

Duoxa1

Duoxa2

Hydrogen peroxide

Cochlea [103]

Thyroid [34, 37]

Lung [125, 354]

GI tract [152, 403, 406]

Salivary gland [403]

None reported