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Table 1 Tissue and cellular distribution of NOX isoforms

From: NADPH oxidase in brain injury and neurodegenerative disorders

ISOFORM Regulators Product Reported Non-CNS Distribution CNS tissue
NOX1 NOXO1 NOXA1 Rac1 PKA PKC MAPK Hsp90 Superoxide Colon [35, 39, 42] Blood vessels [70, 359, 360] Heart [361] Bone marrow [362] Cochlea [103] Cerebral cortex [53, 139] Hippocampus [50, 202] Cerebellum [363] Substantia nigra [364] Striatum [61] Hypothalamus [361] Cerebral vessels [359, 365]
NOX2 P67phox P47phox P40phox Rac Hsp90 Superoxide Vasculature [365, 366] Phagocytes [319, 367] Heart [361, 368, 369] Kidney [370] Gastrointestinal tract [371] Liver [372] Pancreas [373] Cochlea [103] Cerebral cortex [71, 374, 375] Hippocampus [132, 374, 376] Cerebellum [363] Striatum [377, 378] Substantia nigra [379, 380] Hypothalamus [361, 381] Subfornical organ [382] Lateral ventricle [383] Subventricular zone [383] Midbrain [380] Nucleus tractus solitarius [384]
NOX3 NOXA1 NOXO1 Rac p67phox Superoxide Inner ear/Cochlea [100, 102, 103, 385] Lungs [386, 387] Cerebral cortex [71]
NOX4 p22phox PolDip2 PDI Hypoxia mGlu3 PI3K TLR4 Hydrogen peroxide Ubiquitous, including: Kidney [35, 39, 388] Vessels [389, 390] Lung [391394] Bone [39, 362, 395] Placenta [35, 39, 396] Cochlea [103] Cerebral cortex [71, 377, 397] Hippocampus [376] Cerebellum [363] Hypothalamus [361, 381, 398] Subfornical organ [382] Glioblastoma [35]
NOX5 Ca+2 Hsp90 Superoxide Testis [35] Ovary [35] Spleen [35] Kidney [399] Vasculature [400, 401] Uterus [402] Cochlea [103] Tumors [35, 115] Glioblastoma [35, 116]
DUOX1 Ca2+ Duoxa1 Duoxa2 Hydrogen peroxide Thyroid [34, 37] Lung [354, 403, 404] Skin [154, 156, 405] Cochlea [103] None reported
DUOX2 Ca2+ TRIF/NFkB MyD88/p38 Duoxa1 Duoxa2 Hydrogen peroxide Cochlea [103] Thyroid [34, 37] Lung [125, 354] GI tract [152, 403, 406] Salivary gland [403] None reported