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Table 1 Tissue and cellular distribution of NOX isoforms

From: NADPH oxidase in brain injury and neurodegenerative disorders

ISOFORM Regulators Product Reported Non-CNS Distribution CNS tissue
NOX1 NOXO1
NOXA1
Rac1
PKA
PKC
MAPK
Hsp90
Superoxide Colon [35, 39, 42]
Blood vessels [70, 359, 360]
Heart [361]
Bone marrow [362]
Cochlea [103]
Cerebral cortex [53, 139]
Hippocampus [50, 202]
Cerebellum [363]
Substantia nigra [364]
Striatum [61]
Hypothalamus [361]
Cerebral vessels [359, 365]
NOX2 P67phox
P47phox
P40phox
Rac
Hsp90
Superoxide Vasculature [365, 366]
Phagocytes [319, 367]
Heart [361, 368, 369]
Kidney [370]
Gastrointestinal tract [371]
Liver [372]
Pancreas [373]
Cochlea [103]
Cerebral cortex [71, 374, 375]
Hippocampus [132, 374, 376]
Cerebellum [363]
Striatum [377, 378]
Substantia nigra [379, 380]
Hypothalamus [361, 381]
Subfornical organ [382]
Lateral ventricle [383]
Subventricular zone [383]
Midbrain [380]
Nucleus tractus solitarius [384]
NOX3 NOXA1
NOXO1
Rac
p67phox
Superoxide Inner ear/Cochlea [100, 102, 103, 385]
Lungs [386, 387]
Cerebral cortex [71]
NOX4 p22phox
PolDip2
PDI
Hypoxia
mGlu3
PI3K
TLR4
Hydrogen peroxide Ubiquitous, including:
Kidney [35, 39, 388]
Vessels [389, 390]
Lung [391394]
Bone [39, 362, 395]
Placenta [35, 39, 396]
Cochlea [103]
Cerebral cortex [71, 377, 397]
Hippocampus [376]
Cerebellum [363]
Hypothalamus [361, 381, 398]
Subfornical organ [382]
Glioblastoma [35]
NOX5 Ca+2
Hsp90
Superoxide Testis [35]
Ovary [35]
Spleen [35]
Kidney [399]
Vasculature [400, 401]
Uterus [402]
Cochlea [103]
Tumors [35, 115]
Glioblastoma [35, 116]
DUOX1 Ca2+
Duoxa1
Duoxa2
Hydrogen peroxide Thyroid [34, 37]
Lung [354, 403, 404]
Skin [154, 156, 405]
Cochlea [103]
None reported
DUOX2 Ca2+
TRIF/NFkB
MyD88/p38
Duoxa1
Duoxa2
Hydrogen peroxide Cochlea [103]
Thyroid [34, 37]
Lung [125, 354]
GI tract [152, 403, 406]
Salivary gland [403]
None reported