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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Fig. 1

Lrrk2 knockout mice display increased tibial cortical bone strength. Tibiae from 7 female Lrrk2 knockout (KO) and 7 age and sex-matched wild-type (WT) mice displayed no differences in a gross morphology or b trabecular bone architecture. However, micro-computed tomographic analysis of tibial cortical bone revealed c increased second moment of area around the minor axis, Imin; d increased second moment of area around major axis, Imax; and e increased predicted resistance to torsion, J. f Shows a graphical heatmap displaying statistical differences along the tibia between wild-type and knockout mice, using 1-way ANOVA followed by Tukey-Kramer post-hoc analysis (blue = n/s, yellow, p < 0.05, green p < 0.01, red, p < 0.001). Note that in addition to the parameters Imin, Imax and J, other bone parameters were studied, all of which showed differences (see main text for explanation and Additional file 3: Figure S2 and Additional file 4: Figure S3 for raw data). These altered parameters indicate increased bone strength in Lrrk2 null animals

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