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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

Fig. 1

Adult male and female ApoE3-KI and ApoE4-KI mice do not exhibit weight loss upon exposure to 0.2% lead acetate for 12 weeks. a Experimental design and timeline for the behavior cohort. b Body weight was measured every 1–2 weeks during the lead exposure window. The lead-treated mice did not exhibit any weight loss relative to controls of the same sex and genotype. ApoE3-KI mice exposed to lead weighed slightly but significantly more at several time points than control mice during the lead exposure. Data are mean ± SEM with n = 8–13 per genotype/sex/treatment. Two-way ANOVA, significant main effect of treatment: n.s., not significant; * p < 0.05; ** p < 0.01

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