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Fig. 15 | Molecular Neurodegeneration

Fig. 15

From: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

Fig. 15

Lead does not impair the dendritic complexity of immature neurons in the DG of male mice. a, Representative confocal images of DCX (red) immunostaining in the DG of 20-week-old male ApoE3-KI and ApoE4-KI control and lead-treated mice (left scale bar, 100 μm; right scale bar, 25 μm). b, Representative examples of DCX+ neurons from male ApoE3-KI and ApoE4-KI control and lead-treated mice traced using the ImageJ Simple Neurite Tracer plug-in (scale bar, 25 μm). c, Quantification of the total dendritic length of DCX+ neurons in the DG. Sholl analysis of DCX+ neurons from d ApoE3-KI and e ApoE4-KI male mice. Data are mean ± SEM with n = 4–5 per genotype/treatment. Two-way ANOVA with Fisher’s LSD post-test: n.s., not significant

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