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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

Fig. 6

Demonstration of perivascular hemosiderin deposits reflecting ensued microhemorrhages. a Shown is an example of hemosiderin deposition associated with CAA laden vessel in the cerebral cortex of 10D5 mAb treated APP/ε4 animal. The histological section was double-stained with Thioflavin-S and Pearls’ Prussian blue stain for ferric iron and photographed under fluorescence and bright-field microscopy, respectively. Positive perivascular hemosiderin stain (arrowhead) was digitally converted to red color and superimposed on green Thioflavin-S stain of CAA (Merge). An arrow indicates a vessel affected by CAA, without evidence of bleeding. b Representative microphotograph of CCA related hemosiderin deposits (arrowheads) in the brain cortex of 10D5 mAb-treated APP/ε2 mouse. A coronal section of the cerebral cortex was immunostained with anti-Aβ HJ3.4 mAb and counterstained with Pearls’ Prussian blue stain. c Examples of large hemosiderin deposits in the thalamus typical of APP/ε2 mice; Pearl’s iron stain without counterstain. An arrow on the left panel indicates an isolated thalamic hemosiderin deposit in TY11-15 control APP/ε2 animal, while arrowheads on the right panel point at the cluster of large hemosiderin deposits (≥15 μm in diameter) identified in 10D5 mAb treated APP/ε2 mouse. Abbreviations: h-hippocampus, t-thalamus. Scale bars: 75 μm (a), 25 μm (b), 500 μm (c)

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