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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

Fig. 8

Analysis of cerebrovascular disease risk factors. APP/ε2 mice show hypercholesterolemia and obesity. Mean ± SEM of the total serum cholesterol level (a) (n = 5-10/group) and body weight (b) (n = 6-16/group) of untreated Age control, TY11-15 treated control, and 10D5 mAb treated mice determined at the age of 15 months at the conclusion of the experiment. a and (b) p < 0.0001 (one-way analysis of variance); ++++ p < 0.0001, TY11-15 APP/ε2 vs. TY11-15 APP/ε3 and APP/ε4 control mice (Sidak’s post hoc test). Differences between Age control, TY11-15 control, and 10D5 mAb treated mice were non-significant for matching APOE backgrounds (Sidak’s post hoc test); not shown on the graph

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