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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

Fig. 8

Inhibition of PS1-Syt1 interaction alters the number and the morphology of dendritic spines. a Representative images of the dendritic spines in GFP overexpressing neurons, pre-treated for 2 h with scramble or PS1-LNT peptides, and stimulated for 15 min with 50 mM KCl. Scale bar 5 μm. The adjacent bar graph shows the quantification of the dendritic spine density. The values are normalized to the scramble treated cells. The data are presented as mean ± SEM, n = 30, n = number of neurites analyzed per condition in 8 independent experiments. Statistical significance was determined using two-tailed unpaired Student’s t-test, ***p < 0.01. b The bar graph presents quantitative analysis of the relative contribution of the mushroom, stubby and thin dendritic spines to the total spine number in neurons shown in (a). The data are presented as mean ± SEM, n = 50 for scramble and n = 43 for PS1-LNT, n = number of images acquired per condition in 8 independent experiments. Statistical significance was determined using two-way ANOVA followed by a Bonferroni’s post-test, *p < 0.05

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