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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

Fig. 4

tPA promotes oligodendrocyte migration along vessels during development at times of intense migration. a Photomicrographs from spinal sections show representative images (from 3 mice) of tPA (red), CD31 (green) and Olig2 (grey) immunostaining in the right ventral horn of WT mice spinal cords at E13. Right image is a 3D reconstruction from confocal acquisitions (on the left). b Photomicrographs from tissue sections show representative images (from 3 mice per group) of Olig2 (red), CD31 (green), and DAPI (blue) immunostaining in the right ventral horn of WT and tPA−/− mice spinal cords at E13. c Quantification of the percentage of Olig2+ oligodendrocytes close (<10 μm) to vessels in the ventral spinal cord parenchyma outside the pMN domain in WT and tPA−/− mice (mean ± SEM, n = 3 per group; *p < 0.05). d Quantification of the percentage of CD31+ staining area in the ventral spinal cord parenchyma outside the pMN domain in WT and tPA−/− mice (mean ± SEM, n = 3 per group; *p < 0.05). E: embryonic day; OL: oligodendrocyte; pMN domain: motor neuron progenitor domain; WT: wild type. Scale bars: 20 μm

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