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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

Fig. 5

Remyelination is delayed in tPA −/− after white matter damage in adult mice. a Representative high resolution T2 images and b quantification of the lesion size at 1, 3, 7, 14 and 21 days after lysolecithin injection (dpi) in the corpus callosum of WT and tPA−/− mice. (mean ± SEM, n = 5 per group; *p < 0.05 and **p < 0.01 significantly, Mann–Whitney U test). c Photomicrographs from corpus callosum sections (perilesion) show representative images (from 3 mice) of Olig2 immunostaining (red) and DAPI staining (blue) from WT (left) and tPA−/− (right) mice at 3 days post injection (dpi). (Scale bars: 20 μm). d Corresponding quantifications of Olig2+ oligodendrocytes (mean ± SEM, n = 3 per group; *p < 0.05). e Quantification of the percentage of proliferating OLs (Ki67+Olig2+/Olig2+) in the lesion of WT and tPA−/− mice, 3 days post-injection. (mean ± SEM, n = 3 per group). f Photomicrographs from brain sections (corpus callosum lesion) show representative images (from 3 mice per group) of MBP immunostaining (red) in the ipsilateral and contralateral corpus callosum of WT and tPA−/− mice, 14 and 21 days post-injection (dpi). Dotted lines show quantified area limits. (Scale bars: 100 μm). g Corresponding quantifications of MBP fluorescence intensity (mean ± SEM, n = 3 per group; *p < 0.05). AU: arbitrary unit; dpi: days post injection; OL: oligodendrocyte; WT: wild type. tPA −/− : tPA Knock-out

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