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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

Fig. 7

tPA promotes oligodendrocyte migration along vessels after white matter damage. a Photomicrographs from brain sections show representative images (from 3 mice) of tPA (red), CD31 (green) and Olig2 (grey) immunostaining in the corpus callosum lesion of WT mice at 3 days post injection (3 dpi). Right image is a rotation of 3D reconstruction from confocal acquisitions (on the left). b Photomicrographs from tissue sections show representative images (from 3 mice per group) of Olig2 (red), CD31 (green), and DAPI (blue) immunostaining in the corpus callosum (perilesion) of WT and tPA−/− mice spinal cords at 3 days post injection (3 dpi). c Quantification of the percentage of Olig2+ oligodendrocytes close (<10 μm) to vessels in the in the corpus callosum (perilesion) in WT and tPA−/− mice (mean ± SEM, n = 3 per group; *p < 0.05). d Quantification of the percentage of CD31+ staining area in corpus callosum (perilesion) in WT and tPA−/− mice (mean ± SEM, n = 3 per group; *p < 0.05). E: embryonic day; OL: oligodendrocyte; pMN domain: motor neuron progenitor domain; WT: wild type. Scale bars: 10 μm

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