Fig. 3
Chemical structures of the main tau-specific radiotracers. [ 18 F]THK5117: 2-(4-methylaminophenyl)-6-[(3-[18 F]-fluoro-2-hydroxy)propoxy]quinoline; [ 18 F]THK5317: (S)-2-(4-methylaminophenyl)-6-[(3-[18 F]-fluoro-2-hydroxy)propoxy]quinoline; [ 18 F]THK5351: (S)-2-(4-methylaminopyridyl)-6-[(3-[18 F]-fluoro-2-hydroxy)propoxy]quinoline; [ 18 F]T808: 2-(4-(2-[18 F]-fluoroethyl)piperidin-1-yl)benzo[4, 5]imidazo[1,2-a]pyrimidine; [ 18 F]AV-1451: (7-(6- fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; [ 11 C]PBB3: (5-((1E,3E)-4-(6-[11C]methylamino)pyridin-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-ol; [ 18 F]MK-6240: 6-([18 F]-fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine