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Table 2 Targets of the tau tracers

From: Tau PET imaging: present and future directions

 

PBB3

THK5117

THK5351

AV-1451

Binds to

NFTs [28] (ghost tangles and non-ghost tangles [33]);

neuropil threads [28, 33];

neuritic plaques [28, 33] and primitive plaques [33];

dense core amyloid plaques and diffuse amyloid-beta deposits [33];

Pick bodies [28];

astrocytic plaques [28];

tau inclusions in PiD, PSP and CBD [28]

PHFs tau [125];

NFTs[15, 24, 125](both intracellular and extracellular and ghost tangles [125]);

neuritic plaques [125];

argyrophilic grains [125];

argyrophilic threads [125];

globose tangles [125]

NFTs [26];

thread-like structures in the white matter [35];

tufted astrocytes [36]

PHFs tau [18, 31, 37];

NFTs [23, 37] (both intracellular and extracellular [37], mature tangles [31] and ghost tangles [31, 33, 37]);

neuritic plaques and primitive plaques [33] (to a limited extent);

dense core amyloid plaques [33];

melanin-containing structures [31, 37];

lipofuscin-containing structures [31];

mineralized structures [31];

3R + 4R tau deposits (much more than 3R or 4R [31]);

MAO-A [23]

Does not bind to

Pretangles [33]

Pretangles [125];

alpha-synuclein lesions [125];

TDP-43 lesions [125];

Pick bodies [125]

Pretangles [125]

Pretangles [33]

  1. CBD Corticobasal degeneration, MAO-A Monoamine oxidase A, NFT Neurofibrillary tangles, PHF Paired-helical filaments, PiD Pick’s disease, PSP Progressive Supranuclear Palsy, R Repeats (of the microtubule binding domain), TDP-43 transactive-response DNA-binding protein 43
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Molecular Neurodegeneration

ISSN: 1750-1326