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Table 2 Targets of the tau tracers

From: Tau PET imaging: present and future directions

  PBB3 THK5117 THK5351 AV-1451
Binds to NFTs [28] (ghost tangles and non-ghost tangles [33]);
neuropil threads [28, 33];
neuritic plaques [28, 33] and primitive plaques [33];
dense core amyloid plaques and diffuse amyloid-beta deposits [33];
Pick bodies [28];
astrocytic plaques [28];
tau inclusions in PiD, PSP and CBD [28]
PHFs tau [125];
NFTs[15, 24, 125](both intracellular and extracellular and ghost tangles [125]);
neuritic plaques [125];
argyrophilic grains [125];
argyrophilic threads [125];
globose tangles [125]
NFTs [26];
thread-like structures in the white matter [35];
tufted astrocytes [36]
PHFs tau [18, 31, 37];
NFTs [23, 37] (both intracellular and extracellular [37], mature tangles [31] and ghost tangles [31, 33, 37]);
neuritic plaques and primitive plaques [33] (to a limited extent);
dense core amyloid plaques [33];
melanin-containing structures [31, 37];
lipofuscin-containing structures [31];
mineralized structures [31];
3R + 4R tau deposits (much more than 3R or 4R [31]);
MAO-A [23]
Does not bind to Pretangles [33] Pretangles [125];
alpha-synuclein lesions [125];
TDP-43 lesions [125];
Pick bodies [125]
Pretangles [125] Pretangles [33]
  1. CBD Corticobasal degeneration, MAO-A Monoamine oxidase A, NFT Neurofibrillary tangles, PHF Paired-helical filaments, PiD Pick’s disease, PSP Progressive Supranuclear Palsy, R Repeats (of the microtubule binding domain), TDP-43 transactive-response DNA-binding protein 43