Tracer | Publication | Population | Arterial sampling | Plasma-input kinetic model | Reference tissue models | Optimal time-interval for SUVR | Reference region |
---|---|---|---|---|---|---|---|
[18F]AV-1451 | Wooten et al., 2016 [43] |
4 CN, 3 TBI, 2 MCI due to AD | Yes |
1TCM, 2TCM, plasma-input Logan, Multilinear Analysis 1 | Reference Logan | 80–100 min | Cerebellum (excluding the vermis) |
Hahn et al., 2016 [47] |
4 CN, 6 AD, 3 PSP, 2 CBS | Yes |
1TCM, 2TCM, 3TCM, plasma-input Logan* |
SRTM2,
reference Logan* | 80–100 min | Cerebellar cortex (excluding the vermis) | |
Shcherbinin et al., 2016 [42] |
4 young CN, 5 elderly CN, 5 MCI 5 AD dementia | No | - | reference Logan | 80–100 min | Cerebellar crus | |
Baker et al., 2016 [41] |
5 young CN, 23 elderly CN, 15 AD dementia | No | - |
SRTM, SRTM2, reference Logan | 80–100 min | Cerebellar cortex | |
Barret et al., 2016 [48] |
4 young CN, 4 elderly CN, 8 AD dementia | Yes |
1TCM, 2TCM, plasma-input Logan |
SRTM, reference Logan | 80–100 min | Cerebellar cortex | |
[18F]THK5317 ((S)-[18F] THK5117) | Jonasson et al., 2016 [44] |
4 MCI, 5 AD | Yes |
1TCM, 2TCM*, plasma-input Logan |
SRTM,
reference Logan* |
only interval tested: 70–90 min | Cerebellar cortex |
Betthauser et al., 2016 [70] | 14 elderly individuals (ranging from CN to AD dementia) | No | - |
SRTM, MRTM2*, reference Logan | 30–50 min | Cerebellar cortex | |
[18F]THK-5351 | Lockhart et al., 2016 [45] |
6 CN, 10 AD dementia | No | - |
SRTM, reference Logan | 40–60 min | Cerebellar cortex |
Betthauser et al., 2016 [70] | 24 elderly individuals (ranging from CN to AD dementia) | No | - |
SRTM, MRTM2*, reference Logan | 30–50 min | Cerebellar cortex | |
[11C]PBB3 | Kimura et al., 2015 [46] |
7 CN, 7 AD dementia | Yes | Single-input models, Dual-input models (taking metabolites’ activity into account) | MRTM 0 | 30–50 min | Cerebellar cortex |