Table 3 Summary of in vivo kinetic properties of tau tracers

[¹⁸F]AV-1451

Wooten et al., 2016 [43]

4 CN,

3 TBI,

2 MCI due to AD

Yes

1TCM,

2TCM,

plasma-input Logan,

Multilinear Analysis 1

Reference Logan

80–100 min

Cerebellum (excluding the vermis)

Hahn et al., 2016 [47]

4 CN,

6 AD,

3 PSP,

2 CBS

Yes

1TCM,

2TCM,

3TCM,

plasma-input Logan*

SRTM2,

reference Logan*

80–100 min

Cerebellar cortex (excluding the vermis)

Shcherbinin et al., 2016 [42]

4 young CN,

5 elderly CN,

5 MCI

5 AD dementia

No

-

reference Logan

80–100 min

Cerebellar crus

Baker et al., 2016 [41]

5 young CN,

23 elderly CN,

15 AD dementia

No

-

SRTM,

SRTM2,

reference Logan

80–100 min

Cerebellar cortex

Barret et al., 2016 [48]

4 young CN,

4 elderly CN,

8 AD dementia

Yes

1TCM,

2TCM,

plasma-input Logan

SRTM,

reference Logan

80–100 min

Cerebellar cortex

[¹⁸F]THK5317

((S)-[¹⁸F] THK5117)

Jonasson et al., 2016 [44]

4 MCI,

5 AD

Yes

1TCM,

2TCM*,

plasma-input Logan

SRTM,

reference Logan*

only interval tested:

70–90 min

Cerebellar cortex

Betthauser et al., 2016 [70]

14 elderly individuals (ranging from CN to AD dementia)

No

-

SRTM,

MRTM₂*,

reference Logan

30–50 min

Cerebellar cortex

[¹⁸F]THK-5351

Lockhart et al., 2016 [45]

6 CN,

10 AD dementia

No

-

SRTM,

reference Logan

40–60 min

Cerebellar cortex

Betthauser et al., 2016 [70]

24 elderly individuals (ranging from CN to AD dementia)

No

-

SRTM,

MRTM₂*,

reference Logan

30–50 min

Cerebellar cortex

[¹¹C]PBB3

Kimura et al., 2015 [46]

7 CN,

7 AD dementia

Yes

Single-input models, Dual-input models (taking metabolites’ activity into account)

MRTM ₀

30–50 min

Cerebellar cortex