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Table 3 Summary of in vivo kinetic properties of tau tracers

From: Tau PET imaging: present and future directions

Tracer Publication Population Arterial sampling Plasma-input kinetic model Reference tissue models Optimal time-interval for SUVR Reference region
[18F]AV-1451 Wooten et al., 2016 [43] 4 CN,
3 TBI,
2 MCI due to AD
Yes 1TCM,
2TCM,
plasma-input Logan,
Multilinear Analysis 1
Reference Logan 80–100 min Cerebellum (excluding the vermis)
Hahn et al., 2016 [47] 4 CN,
6 AD,
3 PSP,
2 CBS
Yes 1TCM,
2TCM,
3TCM,
plasma-input Logan*
SRTM2,
reference Logan*
80–100 min Cerebellar cortex (excluding the vermis)
Shcherbinin et al., 2016 [42] 4 young CN,
5 elderly CN,
5 MCI
5 AD dementia
No - reference Logan 80–100 min Cerebellar crus
Baker et al., 2016 [41] 5 young CN,
23 elderly CN,
15 AD dementia
No - SRTM,
SRTM2,
reference Logan
80–100 min Cerebellar cortex
Barret et al., 2016 [48] 4 young CN,
4 elderly CN,
8 AD dementia
Yes 1TCM,
2TCM,
plasma-input Logan
SRTM,
reference Logan
80–100 min Cerebellar cortex
[18F]THK5317
((S)-[18F] THK5117)
Jonasson et al., 2016 [44] 4 MCI,
5 AD
Yes 1TCM,
2TCM*,
plasma-input Logan
SRTM,
reference Logan*
only interval tested:
70–90 min
Cerebellar cortex
Betthauser et al., 2016 [70] 14 elderly individuals (ranging from CN to AD dementia) No - SRTM,
MRTM2*,
reference Logan
30–50 min Cerebellar cortex
[18F]THK-5351 Lockhart et al., 2016 [45] 6 CN,
10 AD dementia
No - SRTM,
reference Logan
40–60 min Cerebellar cortex
Betthauser et al., 2016 [70] 24 elderly individuals (ranging from CN to AD dementia) No - SRTM,
MRTM2*,
reference Logan
30–50 min Cerebellar cortex
[11C]PBB3 Kimura et al., 2015 [46] 7 CN,
7 AD dementia
Yes Single-input models, Dual-input models (taking metabolites’ activity into account) MRTM 0 30–50 min Cerebellar cortex
  1. All plasma-input and/or reference tissue models investigated in each study have been tabulated. Models that were described as “suitable” (i.e. for reference tissue models, those in which the reference-tissue model results agreed well with the plasma-input model results) are indicated in bold font. Plasmasinput and reference tissue models that were identified a best or most suitable are labelled with an asterisk (*). AD Alzheimer’s disease, CBS corticobasal syndrome, CN cognitively normal, GM grey matter, MCI mild cognitive impairment, MRTM 0, MRTM 2 multilinear reference tissue models, PSP progressive supranuclear palsy, SRTM simplified reference tissue model, SUVR standard uptake value ratio, TBI traumatic brain injury, TCM tissue compartment model