Skip to main content

Table 3 Summary of in vivo kinetic properties of tau tracers

From: Tau PET imaging: present and future directions

Tracer Publication Population Arterial sampling Plasma-input kinetic model Reference tissue models Optimal time-interval for SUVR Reference region
[18F]AV-1451 Wooten et al., 2016 [43] 4 CN,
3 TBI,
2 MCI due to AD 		Yes 1TCM,
2TCM,
plasma-input Logan,
Multilinear Analysis 1 		Reference Logan 80–100 min Cerebellum (excluding the vermis)
Hahn et al., 2016 [47] 4 CN,
6 AD,
3 PSP,
2 CBS 		Yes 1TCM,
2TCM,
3TCM,
plasma-input Logan* 		SRTM2,
reference Logan* 		80–100 min Cerebellar cortex (excluding the vermis)
Shcherbinin et al., 2016 [42] 4 young CN,
5 elderly CN,
5 MCI
5 AD dementia 		No - reference Logan 80–100 min Cerebellar crus
Baker et al., 2016 [41] 5 young CN,
23 elderly CN,
15 AD dementia 		No - SRTM,
SRTM2,
reference Logan 		80–100 min Cerebellar cortex
Barret et al., 2016 [48] 4 young CN,
4 elderly CN,
8 AD dementia 		Yes 1TCM,
2TCM,
plasma-input Logan 		SRTM,
reference Logan 		80–100 min Cerebellar cortex
[18F]THK5317
((S)-[18F] THK5117) 		Jonasson et al., 2016 [44] 4 MCI,
5 AD 		Yes 1TCM,
2TCM*,
plasma-input Logan 		SRTM,
reference Logan* 		only interval tested:
70–90 min 		Cerebellar cortex
Betthauser et al., 2016 [70] 14 elderly individuals (ranging from CN to AD dementia) No - SRTM,
MRTM2*,
reference Logan 		30–50 min Cerebellar cortex
[18F]THK-5351 Lockhart et al., 2016 [45] 6 CN,
10 AD dementia 		No - SRTM,
reference Logan 		40–60 min Cerebellar cortex
Betthauser et al., 2016 [70] 24 elderly individuals (ranging from CN to AD dementia) No - SRTM,
MRTM2*,
reference Logan 		30–50 min Cerebellar cortex
[11C]PBB3 Kimura et al., 2015 [46] 7 CN,
7 AD dementia 		Yes Single-input models, Dual-input models (taking metabolites’ activity into account) MRTM 0 30–50 min Cerebellar cortex
  1. All plasma-input and/or reference tissue models investigated in each study have been tabulated. Models that were described as “suitable” (i.e. for reference tissue models, those in which the reference-tissue model results agreed well with the plasma-input model results) are indicated in bold font. Plasmasinput and reference tissue models that were identified a best or most suitable are labelled with an asterisk (*). AD Alzheimer’s disease, CBS corticobasal syndrome, CN cognitively normal, GM grey matter, MCI mild cognitive impairment, MRTM 0, MRTM 2 multilinear reference tissue models, PSP progressive supranuclear palsy, SRTM simplified reference tissue model, SUVR standard uptake value ratio, TBI traumatic brain injury, TCM tissue compartment model
Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326