Tau PET imaging: present and future directions

Table 4 Cerebral regions showing significant group differences between AD patients and controls across studies

		CN (n)	AD (n)	Neocortex/Isocortical	Hippocampus	Parahippocampal gyrus	Inferior temporal gyrus	Superior temporal	Lateral occipital lobe	Posterior cingulate	Parietal cortex	Anterior cingulate	Putamen/striatum
[¹⁸F]T807	Johnson et al., 2016 [59]	56	6		NS	+	+			+
[¹⁸F]T807	Cho et al., 2016 [57]	20	20	+	+	+	+	+	a	+	+	+	NS
[¹⁸F]THK5117	Harada et al., 2015 [30]	8	8	+	NS	+	+	+	NS	+	+	NS	NS
[¹⁸F]THK5317	data from Chiotis et al., 2016 [53]	9	9	+	NS	+	+	NS	+	+	+	NS	NS
[¹⁸F]THK5351	Lockhart et al., 2016 [45]	6	10		NS	NS	+		a	+	+	NS	NS

Only regions of interest that were comparable across studies are listed in this table
+ indicates that a significant difference between groups was reported; grey empty cells correspond to cerebral regions that were not reported in the publication
a: a significant difference was found when the whole occipital cortex was assessed. AD Alzheimer’s disease, CN cognitively normal, NS not significant

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