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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

Fig. 5

UPS impairment during epilepsy. a. Representative Western (n = 1 per lane) and graph showing increased polyubiquitination (FK2) in the ipsilateral hippocampus of epileptic C57/Bl6 wild-type mice 14 days post-intraamygdala KA (mean ± sem, *p <0.05 by one-way ANOVA with Fisher’s post hoc test; n = 4 per group). b. Increased chymotrypsin-like proteasome activity in the ipsilateral hippocampus of epileptic C57/Bl6 wild-type mice 14 days post-intraamygdala KA (mean ± sem, *p <0.05 by student’s two-tailed t-test; n = 4 per group). c. Representative photomicrograph (40 x lens) showing co-localization between GFP (green) and the neuronal marker NeuN (red) in the different hippocampal subfields of the ipsilateral hippocampus of UbG76V-GFP reporter mice 14 days post-status epilepticus which was most evident in the DG (arrows). Co-localization of GFP with the astrocyte marker GFAP (red) in the same mice was mainly absent. Scale bar, 50 μm

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