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Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Fig. 10

6 DIV primary cortical neurons derived from Tspan6 wt (Tspan6 +/Y) E14.5 embryos were infected with an empty lentiviral vector (LV-cnt) or a lentiviral vector overexpressing Tspan6 (LV-Tspan6). At 9 DIV neurons were washed and processed for EM analysis. Tspan6 wt neurons that overexpressed Tspan6 (e-h) show alterations by EM consisting of accumulation of electron dense material inside large vesicles (arrow) in the soma compared to control neurons (a-d)

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