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Table 2 NWL-117 levels in mice hippocampi and plasma following carotid artery injectionsa

From: Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

Animal #

Hippocampus

Plasma

Ratiob

1

193

48521

0.004

2

816

3416

0.239

3

67.9

8998

0.008

4

356

7408

0.048

5

879

25425

0.035

  1. aConcentrations are reported in nM
  2. bRatio of [hippocampal]/[plasma]
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Molecular Neurodegeneration

ISSN: 1750-1326