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Table 2 Mean difference and 95% confidence interval in annual cognitive decline according to quartile of lipid concentrations

From: Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly

 

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Cognitive decline for each mmol/L increment

P Trend

TC

 

0.35–3.46 mmol/L

3.47–4.14 mmol/L

4.15–4.84 mmol/L

4.85–8.79 mmol/L

  

N

290

287

293

289

  

Median (mmol/L)

2.88

3.83

4.45

5.38

  

Model 1a

0 (ref.)

−0.10 (−0.33, 0.13)

))

−0.25 (−0.49, −0.01)

−0.26 (−0.52, −0.003)

−0.09 (−0.16, −0.02)

0.009

Model 2b

0 (ref.)

−0.10 (−0.33, 0.13)

−0.26 (−0.50, −0.02)

−0.27 (−0.52, −0.01)

−0.09 (−0.16, −0.02)

0.008

Model 3c

0 (ref.)

−0.12 (−0.36, 0.12)

−0.28 (−0.52, −0.03)

−0.28 (−0.54, −0.02)

−0.10 (−0.17, −0.03)

0.005

LDL-C

 

0.20–1.85 mmol/L

1.86–2.39 mmol/L

2.40–2.97 mmol/L

2.98–5.69 mmol/L

  

N

290

287

291

291

  

Median (mmol/L)

1.51

2.14

2.66

3.44

  

Model 1a

0 (ref.)

−0.24 (−0.47, −0.02)

−0.18 (−0.43, 0.06)

−0.38 (−0.64, −0.12)

−0.14 (−0.25, −0.03)

0.01

Model 2b

0 (ref.)

−0.25 (−0.47, −0.02)

−0.19 (−0.43, 0.06)

−0.40 (−0.66, −0.14)

−0.15 (−0.26, −0.04)

0.008

Model 3c

0 (ref.)

−0.26 (−0.48, −0.03)

−0.20 (−0.45, 0.04)

−0.42 (−0.69, −0.16)

−0.16 (−0.27, −0.04)

0.006

HDL-C

 

1.48–3.18 mmol/L

1.22–1.47 mmol/L

1.01–1.21 mmol/L

0.01–1.00 mmol/L

  

N

293

286

289

291

  

Median (mmol/L)

0.88

1.12

1.32

1.70

  

Model 1a

0 (ref.)

0.12 (−0.11, 0.35)

−0.02 (−0.26, 0.22)

−0.04 (−0.30, 0.21)

0.01 (−0.24, 0.27)

0.91

Model 2b

0 (ref.)

0.12 (−0.12, 0.35)

−0.03 (−0.27, 0.21)9-0.11, 0.36)

−0.03 (−0.29, 0.22)

9–0.27

−0.04 (−0.20, 0.22)

99((

9–0.3

0.02 (−0.23, 0.28)

0.87

Model 3c

0 (ref.)

0.10 (−0.14, 0.34)

−0.04 (−0.29, 0.21)

−0.05 (−0.31, 0.21)

0.01 (−0.25, 0.27)

0.93

TG

 

0.13–0.67 mmol/L

0.68–0.92 mmol/L

0.93–1.32 mmol/L

1.33–8.05 mmol/L

  

N

287

296

287

289

  

Median (mmol/L)

0.54

0.79

1.09

1.89

  

Model 1a

0 (ref.)

0.17 (−0.13, 0.46)

0.14 (−0.15, 0.44)

0.16 (−0.13, 0.45)

0.06 (−0.02, 0.14)

0.13

Model 2b

0 (ref.)

0.17 (−0.12, 0.47)

0.14 (−0.15, 0.44)

0.16 (−0.12, 0.45)

0.06 (−0.02, 0.14)

0.13

Model 3c

0 (ref.)

0.17 (−0.13, 0.47)

0.14 (−0.16, 0.44)

0.18 (−0.11, 0.47)

0.06 (−0.02, 0.14)

0.12

  1. Abbreviation: TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, TG triglyceride
  2. aAdjusted for age, sex and education (illiteracy, 1–6 years, or ≥6 years)
  3. bAdjusted for age, sex, education, smoking status (non-smoker and smoker (0.7–20.4, 20.5–44.4, or 44.5–220 pack-year)), alcohol intake (non-drinker and drinker (0.4–2.11, 2.12–4.67, or 4.68–67.7 servings/d)), physical activities (yes/no), depression symptoms (yes/no)
  4. cAdjusted for age, sex, education, smoking status, alcohol intake, physical activity, depression, BMI (<17.5, 17.5–23.0, 23.0–27.9, or ≥28.0 kg/m2), waist circumference (50–73, 74–80, 81–88, or 89–155 cm), hypertension (yes/no), plasma glucose (0.15–3.93, 3.94–4.68, 4.69–5.41, or 5.42–36.04 mmol/L), C-reactive protein (<1, 1–2.9, or ≥3 mg/L) and uric acid (women: <240, 240–360, or ≥360; men: <240, 240–420, or ≥420 μmol/L)
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Molecular Neurodegeneration

ISSN: 1750-1326