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Table 2 Mean difference and 95% confidence interval in annual cognitive decline according to quartile of lipid concentrations

From: Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly

  Quartile 1 Quartile 2 Quartile 3 Quartile 4 Cognitive decline for each mmol/L increment P Trend
TC
  0.35–3.46 mmol/L 3.47–4.14 mmol/L 4.15–4.84 mmol/L 4.85–8.79 mmol/L   
N 290 287 293 289   
Median (mmol/L) 2.88 3.83 4.45 5.38   
Model 1a 0 (ref.) −0.10 (−0.33, 0.13) )) −0.25 (−0.49, −0.01) −0.26 (−0.52, −0.003) −0.09 (−0.16, −0.02) 0.009
Model 2b 0 (ref.) −0.10 (−0.33, 0.13) −0.26 (−0.50, −0.02) −0.27 (−0.52, −0.01) −0.09 (−0.16, −0.02) 0.008
Model 3c 0 (ref.) −0.12 (−0.36, 0.12) −0.28 (−0.52, −0.03) −0.28 (−0.54, −0.02) −0.10 (−0.17, −0.03) 0.005
LDL-C
  0.20–1.85 mmol/L 1.86–2.39 mmol/L 2.40–2.97 mmol/L 2.98–5.69 mmol/L   
N 290 287 291 291   
Median (mmol/L) 1.51 2.14 2.66 3.44   
Model 1a 0 (ref.) −0.24 (−0.47, −0.02) −0.18 (−0.43, 0.06) −0.38 (−0.64, −0.12) −0.14 (−0.25, −0.03) 0.01
Model 2b 0 (ref.) −0.25 (−0.47, −0.02) −0.19 (−0.43, 0.06) −0.40 (−0.66, −0.14) −0.15 (−0.26, −0.04) 0.008
Model 3c 0 (ref.) −0.26 (−0.48, −0.03) −0.20 (−0.45, 0.04) −0.42 (−0.69, −0.16) −0.16 (−0.27, −0.04) 0.006
HDL-C
  1.48–3.18 mmol/L 1.22–1.47 mmol/L 1.01–1.21 mmol/L 0.01–1.00 mmol/L   
N 293 286 289 291   
Median (mmol/L) 0.88 1.12 1.32 1.70   
Model 1a 0 (ref.) 0.12 (−0.11, 0.35) −0.02 (−0.26, 0.22) −0.04 (−0.30, 0.21) 0.01 (−0.24, 0.27) 0.91
Model 2b 0 (ref.) 0.12 (−0.12, 0.35) −0.03 (−0.27, 0.21)9-0.11, 0.36) −0.03 (−0.29, 0.22) 9–0.27 −0.04 (−0.20, 0.22) 99(( 9–0.3 0.02 (−0.23, 0.28) 0.87
Model 3c 0 (ref.) 0.10 (−0.14, 0.34) −0.04 (−0.29, 0.21) −0.05 (−0.31, 0.21) 0.01 (−0.25, 0.27) 0.93
TG
  0.13–0.67 mmol/L 0.68–0.92 mmol/L 0.93–1.32 mmol/L 1.33–8.05 mmol/L   
N 287 296 287 289   
Median (mmol/L) 0.54 0.79 1.09 1.89   
Model 1a 0 (ref.) 0.17 (−0.13, 0.46) 0.14 (−0.15, 0.44) 0.16 (−0.13, 0.45) 0.06 (−0.02, 0.14) 0.13
Model 2b 0 (ref.) 0.17 (−0.12, 0.47) 0.14 (−0.15, 0.44) 0.16 (−0.12, 0.45) 0.06 (−0.02, 0.14) 0.13
Model 3c 0 (ref.) 0.17 (−0.13, 0.47) 0.14 (−0.16, 0.44) 0.18 (−0.11, 0.47) 0.06 (−0.02, 0.14) 0.12
  1. Abbreviation: TC total cholesterol, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, TG triglyceride
  2. aAdjusted for age, sex and education (illiteracy, 1–6 years, or ≥6 years)
  3. bAdjusted for age, sex, education, smoking status (non-smoker and smoker (0.7–20.4, 20.5–44.4, or 44.5–220 pack-year)), alcohol intake (non-drinker and drinker (0.4–2.11, 2.12–4.67, or 4.68–67.7 servings/d)), physical activities (yes/no), depression symptoms (yes/no)
  4. cAdjusted for age, sex, education, smoking status, alcohol intake, physical activity, depression, BMI (<17.5, 17.5–23.0, 23.0–27.9, or ≥28.0 kg/m2), waist circumference (50–73, 74–80, 81–88, or 89–155 cm), hypertension (yes/no), plasma glucose (0.15–3.93, 3.94–4.68, 4.69–5.41, or 5.42–36.04 mmol/L), C-reactive protein (<1, 1–2.9, or ≥3 mg/L) and uric acid (women: <240, 240–360, or ≥360; men: <240, 240–420, or ≥420 μmol/L)