Fig. 4

Cognitive decline trajectories of MAP participants ranked by cortical FADD levels. Global cognitive function was evaluated annually after enrolment, for 5.6 years in average (range 3–12 years), and the scores were standardized as described in Methods. Participants were then aligned longitudinally by the last cognitive test before death. Participants were divided into groups according to their tertile of FADD cortical expression levels. The spaghetti plot on the left represents individual cognitive trajectories across the study. The panel on the right represents individual annual scores (points), with the best fit (solid line) and the 95% confidence interval (shaded area) of the cognitive trajectories for each FADD-ranked group overlapped