| |
Clinical dementiaa
|
Cognitive functionb
|
|---|
|
Model terms
|
Odds ratio
|
95% CI
|
P-value
|
Estimate
|
SD
|
P-value
|
|---|
|
Age at death
|
1.104
|
1.025–1.197
|
0.0117*
|
−0.0293
|
0.0118
|
0.0144*
|
|
Sex
|
1.231
|
0.440-3.433
|
0.6887
|
0.0856
|
0.0818
|
0.2976
|
|
Education years
|
1.133
|
0.966–1.339
|
0.1319
|
−0.0278
|
0.0260
|
0.2877
|
|
PMI
|
0.928
|
0.804–1.039
|
0.2401
|
−0.0052
|
0.0203
|
0.7991
|
|
APOE ε4 allele
|
0.752
|
0.235–2.267
|
0.6195
|
0.0369
|
0.0921
|
0.6892
|
|
Macroinfarctsc
|
1.295
|
0.498–3.328
|
0.5913
|
−0.1040
|
0.1616
|
0.5208
|
|
Lewy bodiesc
|
9.190
|
2.833–35.790
|
0.0005*
|
−0.5993
|
0.1971
|
0.0028*
|
|
Hipp. sclerosis
|
3.935
|
0.832–21.845
|
0.0930
|
−0.1160
|
0.2813
|
0.6808
|
|
Arteriolosclerosisc
|
1.271
|
0.783–2.090
|
0.3350
|
−0.1022
|
0.0824
|
0.2166
|
|
Amyloid plaquesd
|
1.366
|
0.974–1.948
|
0.0756
|
−0.1186
|
0.0588
|
0.0458*
|
|
Tanglesd
|
1.040
|
0.906–1.208
|
0.5865
|
−0.0887
|
0.0265
|
0.0011*
|
|
Synaptic densitye
|
1.798
|
0.895–3.891
|
0.1151
|
−0.1003
|
0.1065
|
0.3475
|
|
FADDf
|
0.433
|
0.248–0.717
|
0.0019*
|
0.4993
|
0.1840
|
0.0075*
|
-
Abbreviations: C.I. confidence intervals, DLPFC dorsolateral prefrontal cortex, FADD Fas-associated protein with death domain, Hipp., hippocampal, MAP Memory and Aging Project, MCI mild cognitive impairment, NCI no cognitive impairment, PMI postmortem interval, S.D., standard deviation, SNAP-25, synaptosomal-associated protein of 25 kDa, VAMP, vesicle-associated membrane protein
-
aLogistic regression model of the estimated odds ratios of clinical dementia vs. non-dementia (i.e. NCI and MCI participants) per unit of regressor
-
bLinear regression model predicting global cognitive function nearest to death
-
cGlobal values
-
dValues obtained in the contralateral DLPFC by immunohistochemistry with specific antibodies
-
eEstimated as the mean value of calculated densities of the presynaptic proteins syntaxin-1, SNAP-25 and VAMP in the same brain samples
-
fValues normalized by β-actin
- *Statistically significant P-value < 0.05
