Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

Table 2 Regression models showing the associations of FADD levels in the DLPFC of MAP participants (and relevant covariates) with clinical dementia and cognitive function

Abbreviations: C.I. confidence intervals, DLPFC dorsolateral prefrontal cortex, FADD Fas-associated protein with death domain, Hipp., hippocampal, MAP Memory and Aging Project, MCI mild cognitive impairment, NCI no cognitive impairment, PMI postmortem interval, S.D., standard deviation, SNAP-25, synaptosomal-associated protein of 25 kDa, VAMP, vesicle-associated membrane protein
^aLogistic regression model of the estimated odds ratios of clinical dementia vs. non-dementia (i.e. NCI and MCI participants) per unit of regressor
^bLinear regression model predicting global cognitive function nearest to death
^cGlobal values
^dValues obtained in the contralateral DLPFC by immunohistochemistry with specific antibodies
^eEstimated as the mean value of calculated densities of the presynaptic proteins syntaxin-1, SNAP-25 and VAMP in the same brain samples
^fValues normalized by β-actin
*Statistically significant P-value < 0.05

ISSN: 1750-1326