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Table 2 Regression models showing the associations of FADD levels in the DLPFC of MAP participants (and relevant covariates) with clinical dementia and cognitive function

From: Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

  Clinical dementiaa Cognitive functionb
Model terms Odds ratio 95% CI P-value Estimate SD P-value
Age at death 1.104 1.025–1.197 0.0117* −0.0293 0.0118 0.0144*
Sex 1.231 0.440-3.433 0.6887 0.0856 0.0818 0.2976
Education years 1.133 0.966–1.339 0.1319 −0.0278 0.0260 0.2877
PMI 0.928 0.804–1.039 0.2401 −0.0052 0.0203 0.7991
APOE ε4 allele 0.752 0.235–2.267 0.6195 0.0369 0.0921 0.6892
Macroinfarctsc 1.295 0.498–3.328 0.5913 −0.1040 0.1616 0.5208
Lewy bodiesc 9.190 2.833–35.790 0.0005* −0.5993 0.1971 0.0028*
Hipp. sclerosis 3.935 0.832–21.845 0.0930 −0.1160 0.2813 0.6808
Arteriolosclerosisc 1.271 0.783–2.090 0.3350 −0.1022 0.0824 0.2166
Amyloid plaquesd 1.366 0.974–1.948 0.0756 −0.1186 0.0588 0.0458*
Tanglesd 1.040 0.906–1.208 0.5865 −0.0887 0.0265 0.0011*
Synaptic densitye 1.798 0.895–3.891 0.1151 −0.1003 0.1065 0.3475
FADDf 0.433 0.248–0.717 0.0019* 0.4993 0.1840 0.0075*
  1. Abbreviations: C.I. confidence intervals, DLPFC dorsolateral prefrontal cortex, FADD Fas-associated protein with death domain, Hipp., hippocampal, MAP Memory and Aging Project, MCI mild cognitive impairment, NCI no cognitive impairment, PMI postmortem interval, S.D., standard deviation, SNAP-25, synaptosomal-associated protein of 25 kDa, VAMP, vesicle-associated membrane protein
  2. aLogistic regression model of the estimated odds ratios of clinical dementia vs. non-dementia (i.e. NCI and MCI participants) per unit of regressor
  3. bLinear regression model predicting global cognitive function nearest to death
  4. cGlobal values
  5. dValues obtained in the contralateral DLPFC by immunohistochemistry with specific antibodies
  6. eEstimated as the mean value of calculated densities of the presynaptic proteins syntaxin-1, SNAP-25 and VAMP in the same brain samples
  7. fValues normalized by β-actin
  8. *Statistically significant P-value < 0.05
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