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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

Fig. 3

DcR3 suppressed Aβ-induced neurotoxicity in primary neuronal cultures. a Schematic of in vitro Aβ and DcR3 treatment conditions. Microglia were stimulated with b, d, e oligomeric and c, f fibrillar Aβ for 72 h with the addition of DcR3 at different time points, and their conditioned media (CM) were collected for treating onto primary neurons. The survival rates of primary neurons after 72 h incubating with different CM were determined by MTT assay. b-c The survival rate of primary neuron treated with CM from microglia exposing to DcR3 at 8 h before stimulating with Aβ. d The survival rate of primary neuron treated with CM from microglia exposing to DcR3 at 0, 24 and 48 h after stimulating with Aβ. e, f The survival rate of primary neuron treated with Aβ-CM in addition with DcR3. N ≥ 3 independent experiments. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001

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