DcR3 modulated the phagocytic ability of microglia. a Representative confocal IHC images of Iba1+ microglia (green) and Aβ plaques (red) in APP and APP/DcR3 mice. Scale bar: 20 μm.
b Quantification of colocalization of activated microglia and plaques. The ratio is calculated as (area of microglia)/(area of plaque) in the region of interest. Number of plaques analyzed: APP = 342, APP/DcR3 = 324 from at least 3 mice per genotype. ***P < 0.001 versus APP. c Representative confocal images of oAβ- or oAβ + DcR3-treated primary microglia with engulfed microspheres. Scale bar: 10 μm.
d The number of microspheres engulfed per cell was quantified by using MetaMorph. N = 74–76 cells per condition. ***P ≤ 0.001 versus oAβ group