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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Dioxins and related environmental contaminants increase TDP-43 levels

Fig. 2

Peripheral exposure to AHR agonists elevates TDP-43 protein levels in the brain. a Immunoblot of cortical tissue from mice exposed by intraperitoneal (i.p) injection to the AHR agonist 7,12-Dimethylbenz(a)anthracene (DMBA). b Densitometric analysis of TDP-43 from immunoblots reveals that peripheral i.p. exposure to DMBA leads to a significant increase in cortical TDP-43 protein, an effect that is substantially reversed by the co-injection of the AHR antagonist CB7993113. N = 6 mice per group; mean ± SEM, ANOVA w/Tukey’s; *** P < 0.001, * P < 0.05. c Scatter of normalized Tardbp mRNA levels of individual mice detected by qPCR, with means and 95% confidence intervals. N = 5 mice per group; mean ± SEM

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