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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Fig. 4

Oxygen consumption and extracellular acidification rates are unchanged in TDP-43 mutant human fibroblasts. a Baseline oxygen consumption rate (OCR base) expressed as pmol oxygen consumed per minute per mg of cellular proteins in control skin fibroblasts (n = 8 cell lines) and in fibroblasts harboring a TDP-43 N352S point mutation associated with ALS-FTLD (n = 3 cell lines). b Oligomycin sensitive oxygen consumption rate (OCR OSR) indicating the ATP synthetic component of OCR. c Maximal uncoupled respiratory capacity after FCCP addition (OCR max). d OCR spare (difference between base and maximum capacity) indicating the reserve respiratory capacity. e Baseline extracellular acidification rate (ECAR base), expressed as mpH per minute per mg of cellular proteins, indicating glycolytic flux. f ECAR/OCR ratio indicating glycolytic vs. oxidative metabolism. All lines were tested in 12 technical over three biological replicates

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