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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Fig. 5

Mitochondrial membrane potential, mitochondrial mass, and ATP content are unchanged in TDP-43 mutant human fibroblasts. a Mitochondrial membrane potential estimated fluorimetrically with the potentiometric die TMRM. b Mitochondrial mass estimated fluorimetrically with Mito Tracker Green (MTG). c Mitochondrial membrane potential normalized by mitochondrial mass (TMRM/MTG). d Total cellular ATP content under standard growth conditions. e Total cellular ATP content under conditions of glycolytic inhibition. f Total cellular ATP content under conditions of mitochondrial ATP synthesis inhibition. n = 8 control skin fibroblasts cell lines and n = 3 TDP-43 N352S fibroblasts cell lines. All lines were tested in 8 technical over three biological replicates

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