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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Fig. 3

Brain O-protein levels following acute Thiamet G treatment. C57BL6 mice (n = 8 per group) were given a single oral dose of vehicle (water) or Thiamet G at 10 or 500 mg/kg. Brain and plasma were collected 6 h after dosing. a Concentrations of Thiamet G in plasma (right) and brain (left). b Elevation of O-protein in total brain homogenates after Thiamet G treatment. All data shown are the mean ± SEM. Each sample was assayed in duplicate

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