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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Fig. 4

Effect of chronic treatment of rTg4510 mice with Thiamet G on body weight, food intake and brain O-protein. rTg4510 mice (n = 35 per group) were treated with Thiamet G (500 mg/kg/day in the diet) either for 8 weeks from 8 to 16 weeks of age or for 4 weeks from 12 to 16 weeks of age. Body weight and food consumption were monitored weekly. Plasma and brains were collected at the end of the study. Baseline groups of naïve (untreated) rTg4510 mice were also sacrificed at 8 or 12 weeks of age (n = 10 per age group). a Body weight and b food intake as measured weekly during the 8 weeks of the study. Animals in all groups showed an increase in body weight and food intake during the treatment period (p < 0.0001), but no significant differences were observed between the treatment groups (body weight, p = 0.6, food intake, p = 0.22). c and d Plasma and brain Thiamet G concentrations (c) and O-protein levels in total brain homogenates (d) measured at the end of the study. The data shown are the mean ± SEM. Each sample was assayed in duplicate

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