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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Fig. 6

Effects of chronic Thiamet G treatment of rTg4510 mice on CSF tau. Thiamet G (500 mg/kg/day) or vehicle were administered in diet to rTg4510 mice (n = 35 per group) from either 8–16 or 12–16 weeks of age. Baseline animals (n = 10 per group) were sacrificed at the indicated age and did not receive any treatment. Eight weeks of treatment with Thiamet G treatment significantly reduced CSF total tau (a; *p < 0.05 by t-test) and CSF pT181 tau (b), although the latter effect did not reach statistical significance. CSF total tau and pT181 tau were measured as described in Methods. The data shown are the mean ± SEM. Each sample was assayed in duplicate. c Statistically significant correlation of CSF total tau and pT181 tau in vehicle and Thiamet G-treated groups (r2 = 0.86, p < 0.0001)

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