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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Fig. 1

Summary of distribution of αSyn pathology in Line M20 mice following intrastriatal injection of human or mouse αSyn fibrils. In Cohorts 1 and 2, mice were injected with human (hu) WT αSyn fibrils (Cohort 1) or mouse (ms) WT αSyn fibrils (Cohort 2) in the IC area whereas Cohort 3 mice were injected with human WT αSyn fibrils in the CPu. The total number of mice injected in each cohort as well as the number of mice actually displaying αSyn pathology is depicted (denoted as +ve n/Total n). Rostro-caudal distribution of αSyn inclusions is presented on a schematic brain and spinal cord map, with red dots depicting the relative abundance of αSyn inclusions in different brain and spinal cord locations. The numbers on top of the brain map schematics correspond to plates from the Paxinos Brain Atlas [57]

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