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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Fig. 6

Intrastriatal injection of αSyn fibrils in NTG mice does not result in nigral DA neurodegeneration. NTG mice were injected in the IC (Cohort 4, injected with mouse αSyn fibrils and Cohort 5, injected with human αSyn fibrils) or CPu (Cohort 6; injected with mouse αSyn fibrils). Representative TH staining depicting DA neurons in the dorsal and ventral aspects of SN are shown (left and right panels respectively). The total number of TH-immunostained neurons were unaltered in all cohorts compared to PBS injected mice. Scale Bar, 100 μm; n = 3–5/cohort

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